Early Stage Researcher: Agnieszka Wegrzyn, University Medical Centre Groningen

 

Work Place      Home Country
 
Netherlands   Poland

The title of Agnieszka’s project: Modelling of peroxisome metabolism

Agnieszka will construct computer models of yeast and mammalian peroxisome metabolism (in collaboration with the company Lifeglimmer, Berlin). Agnieszka will also collaborate with the companies MDiscoveries (Potsdam) and Evitra (Stockholm) to measure enzyme kinetics, to perform fluxomics and metabolomics analysis and to produce recombinant proteins. Analyses of mutant and patient cell lines will be performed at the Amsterdam Medical Centre. Together with the supervisor Agnieszka coordinates the design of experiments that are required (i) as input for modelling and (ii) to test hypotheses generated by modelling. Agnieszka will build models of relevant novel pathways and interrogate models with respect to diagnosis, biomarkers which will lead to novel therapeutic approaches for peroxisome disorders.

Part of the research will be performed at the Amsterdam Medical Centre and Lifeglimmer (Berlin).

Supervisor: Professor Barbara M. Bakker (b.m.bakker@med.umcg.nl)

Co-Supervisor: Prof. Dr. Martins Dos Santos, Lifeglimmer Berlin

OUTREACH ACTIVITIES:

Poster presentations:

  • 4th Open European Peroxisome Meeting, Neuss, Germany, 9.-11.9.2014, poster title:
    Zoom-out and zoom-in. Defects in human peroxisomal fatty-acid oxidation pathways studied through genome-scale and dynamic models
  • International Study Group for Systems Biology, Durham, UK, 1-5.09.2014, poster title:
    Zoom-out and zoom-in. Defects in human peroxisomal fatty-acid oxidation pathways studied through genome-scale and dynamic models
  • Advanced lecture course in Systems Biology, Innsbruck, Austria, 2-8.03.2014, poster title: “Systems Biology of peroxisomal fatty-acid oxidation and disease
  • PERFUME Kick-off conference, Groningen, The Netherlands, 2-4.12.2013, poster title: “Modelling of peroxisomal fatty-acid oxidation
  • SB@NL, Systems biology symposium, Egmond aan Zee, The Netherlands, 25-26.11.2013, poster title: “Modelling of peroxisomal fatty-acid oxidation

 

Oral presentations:

  • 4th Open European Peroxisome Meeting, Neuss, Germany, 9-11.9.2014, presentation title: ”Zoom-out. Defects in human peroxisomal fatty-acid oxidation pathways studied through genome-scale models
  • International Study Group for Systems Biology, Durham, UK, 1-5.09.2014, presentation title: ”Zoom-out and zoom-in. Defects in human peroxisomal fatty-acid oxidation pathways studied through genome-scale and dynamic models”, Best speaker award

For further information and interest, please contact:

Agnieszka Wegrzyn
Systems Biology Centre for Energy Metabolism and Aging
Department of Paediatrics, Centre for Liver, Digestive and Metabolic Diseases
University Medical Centre Groningen
Antonius Deusinglaan 1
9713AV Groningen
The Netherlands

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Delphine Crappe and Piotr Lisik have defended their thesis

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Delphine Crappe and Piotr Lisik have defended their thesis...

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